Responsibilities include:

• Developing a Cyclic Ion Mobility-Mass Spectrometry (Cyclic IM-MS) method for diastereomeric analysis of synthetic oligonucleotides, aiming for high precision and regulatory compliance.
• Conducting diastereomer profiling and impurity characterization of oligonucleotide drug products, with emphasis on optimized analytical separation.

Responsibilities include:

• Served as a Graduate Research and Teaching Assistant
• During the second year as a TA, worked on designing the “PESC 709: Pharmaceutical Engineering Lab II” course and establishing a new teaching lab
• TA responsibilities involved syllabus design, paper grading, and delivering lectures
• As an RA, engaged in the project titled “LC-MS based quantitative proteomic analysis of macrophages”
• RA responsibilities involve literature review, research design, data collection, statistical analysis, collaboration with different research groups, and communication of findings through conference presentations and journal publications

Responsibilities include:

• Established and validated a microchip CE-MS method utilizing ZipChip for quantitative impurity analysis in synthetic oligonucleotides, ensuring robustness, sensitivity, precision, accuracy, and linearity according to regulatory guidance.
• Conducted characterization and impurity profiling of complex drug products using advanced microchip CE-MS technology, studying matrix effects on the analytical process.
• Gained proficiency in chip-based CE separation and high-resolution mass spectrometry, applying new pharmaceutical analysis techniques beyond formal academic programs.
• Prepared Standard Operating Procedures (SOPs) to ensure compliance and consistency in analytical methods.
• Utilized data processing software to analyze complex datasets, contributing to innovative research in synthetic oligonucleotide analysis.
• Prepared periodic work summaries and delivered weekly presentations to the research team.
• Compiled a technical report on the development and validation of the ZipChip CE-MS method for oligonucleotide analysis.
• Delivered a final oral presentation on project findings to the entire office, showcasing research outcomes and methodologies.
• Completed FDA 101 training course.
• Completed a 2-month workshop on Physiologically-Based Pharmacokinetic Modeling, conducted by Dr. Raymond Yang.

Responsibilities include:

• Responsibilities encompassed literature review, research design, data collection, statistical analysis, collaboration with team members, and communication of findings through conference presentations and journal publications
• Contributed to a project focused on formulating a lipid-based targeted nanocarrier for intranasal codelivery of lapatinib and ketoconazole
• Also worked on another project titled “Preclinical efficacy of TN-1008”

Responsibilities include:

• evaluating different ways of synthesizing nanoparticles, conjugation with antibiotics, characterization of both particles and complexes, testing their antimicrobial properties, analyzing, and documenting all findings, and writing reports.

Responsibilities include:

• Compiling recipes and annexures for submission to the Drugs Administration.
• Generating requisitions for raw and packaging materials for new products in accordance with specified criteria.
• Overseeing the production process, including lab batches, pilot batches, stability batches, trial batches, and scale-up batches for new products.
• Collaborating with Production, QA, Engineering, Marketing, TSD, and Commercial departments.
• Reviewing formulations of existing products in response to product or market complaints, stability-related issues, or cost-saving requirements.
• Developing and updating documentation such as specifications, formulations, process sheets, validation protocols, product manuals, dossiers, procedures, and instructions adhering to cGMP & ISO standards.
• Conducting analytical method development in line with USP, BP, and other compendia and formularies.
• Performing stability studies as outlined in the protocol.