Projects

The adenosine deaminase acting on RNA (ADAR) enzymes that have been identified to specifically recognizes and edits double-stranded RNA (dsRNA), catalyze the Adenosine-to-Inosine (A-to-I) RNA editing. They are widely expressed in most of higher eukaryotes, where tens of thousands of posttranscriptional editing of A-to-I conversions happen in inverted repeats that form long dsRNAs such as the Alu element.

According to American Cancer Society, lung cancer was accountable for over 142,000 deaths in the USA in 2019. About 20% of all NSCLC patients are expected to harbor an EGFR activating mutation.

GBM is the most common and lethal malignant primary brain tumor in adults, and current standardof-care treatment has only limited therapeutic efficacy. We propose to develop and test a novel radioimmunotherapy strategy by rationally combining conformal radiation, a clinically translatable neoantigen nanovaccine, and immune checkpoint blockade to promote tumor response and prolong survival in an orthotopic preclinical GBM model.

In the realm of cancer treatment, conventional therapies frequently fall short in achieving complete tumor eradication and preventing recurrence or metastasis in lung cancer patients. A significant contributing factor to these limitations is the presence of cancer stem cells (CSCs).

Nanotechnology is a rapidly developing field of new therapeutic and diagnostic concept in all areas of medicine. Due to unique characteristics, nanoparticles are considered to have wide applications in detection of biomolecules, drug delivery and release.