Nanoparticle conjugated antibiotics can be a promising means for withstanding drug resistance. The nanoparticle is supposed to increase antibiotic efficacy providing a synergistic effect. We focus here mainly on AgNP conjugated penicillin. Our primary goal is synthesizing silver nanoparticles and evaluating their antibacterial efficacy while co-administering with penicillin such as benzylpenicillin, ampicillin, amoxicillin, etc.